Anxiety and depression are significant concerns among antenatal women in Bangladesh. Despite the critical need for tailored mental health care in health facilities, studies on these symptoms in this demographic remain lacking. Therefore, our study aimed to assess the levels, distribution, and associated factors of depressive and anxiety symptoms and their co-occurrence among women seeking antenatal care at a public healthcare facility in Bangladesh. We conducted a cross-sectional study between May 2024, and June 2024, among women seeking antenatal care (ANC) care in Durgapur Upazila Health Complex, a primary-level public health facility in Bangladesh.