Several SARS‐CoV‐2 variants of concern (VOCs) have emerged and spread globally since 2021, including in Bangladesh. Omicron is the latest edition, first identified in South Africa in November 2021 and arrived in Bangladesh in December 2021. This variant frequently changed with different sublineages, especially BA.1, BA.2, BA.5, and XBB, replacing one by another over time. The clinical consequence of these shifts has been less explored. As part of the countrywide COVID‐19 testing network, International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) has been monitoring SARS‐CoV‐2 variants since January 2021. Here, we describe the emergence and comparative clinical manifestations in patients infected with different Omicron sublineages.